Rejuran Salmon DNA: The Regenerative Skin Treatment Transforming Aesthetic Medicine
Rejuran is a cutting-edge regenerative injectable treatment that has gained global popularity in aesthetic medicine for its ability to repair damaged skin, stimulate collagen production, and improve overall skin quality. Originating from South Korea, Rejuran is part of a new generation of treatments that focus on skin healing and regeneration rather than simply adding volume or filling wrinkles.
Often referred to as “salmon DNA therapy”, Rejuran works by injecting purified polynucleotides derived from salmon DNA into the skin to stimulate natural repair processes at a cellular level.
What Is Rejuran?
Rejuran is an injectable skin rejuvenation treatment containing polynucleotides (PN) or PDRN (polydeoxyribonucleotide) — fragments of DNA extracted and purified from salmon.
These molecules are highly biocompatible with human tissue, meaning they can integrate into the skin and stimulate repair without causing rejection.
Unlike dermal fillers that add volume, Rejuran is considered a “skin healer” or regenerative treatment because it works by improving the health and function of the skin itself.
Where Rejuran Comes From
Rejuran was developed in South Korea by PharmaResearch Products Co., Ltd, a biotechnology company specializing in regenerative medicine.
The active ingredient is derived from purified salmon DNA extracted from salmon sperm cells.
The specific species commonly used is Korean Chum Salmon (Oncorhynchus keta), chosen because its DNA structure closely resembles human DNA, making it highly compatible with human tissue.
The DNA is then:
Extracted
Highly purified
Broken into small fragments (polynucleotides)
Sterilized and formulated for injection
This process creates a safe, medical-grade injectable used in dermatology and aesthetic medicine.
How Rejuran Works (The Science)
Rejuran works through biostimulation and tissue regeneration.
Once injected into the dermis layer of the skin, the polynucleotides:
1. Stimulate Skin Repair-
The DNA fragments activate the skin’s natural repair processes and support regeneration of damaged cells.
2. Increase Collagen Production-
They stimulate fibroblasts — the cells responsible for producing collagen and elastin.
3. Improve Skin Structure-
Over time, this leads to stronger dermal architecture and improved elasticity.
4. Reduce Inflammation-
Polynucleotides also have anti-inflammatory effects that support healing and recovery.
5. Enhance Microcirculation-
The treatment helps improve blood flow and oxygen delivery to skin cells, which supports tissue regeneration.
Benefits of Rejuran
Rejuran is widely used because it improves skin quality rather than simply changing facial structure.
Common benefits include:
Skin rejuvenation
Improves overall skin health, thickness and resilience.
Collagen stimulation
Boosts collagen and elastin production leading to firmer skin.
Improved texture
Reduces rough skin and uneven texture.
Reduction of fine lines
Softens fine lines and early wrinkles.
Acne scar improvement
Helps repair damaged dermal tissue.
Increased hydration
Improves skin barrier function and moisture retention.
Brighter skin tone
Enhances luminosity and radiance.
Reduced pore size
Helps tighten and refine enlarged pores.
Under-eye rejuvenation
Often used to improve dark circles and thin skin around the eyes.
What Rejuran Is Commonly Used For in Aesthetics
Rejuran is extremely versatile and can be used across multiple areas of the face and body.
Face
Fine lines and wrinkles
Poor skin texture
Dull or dehydrated skin
Early aging
Enlarged pores
Under eyes
Dark circles
Thin skin
Crepey texture
Acne scars
Atrophic acne scars
Skin damage from inflammation
Neck and décolletage
Sun damage
Skin thinning
Hands
Skin rejuvenation
Fine wrinkles
It is also often combined with other treatments such as:
microneedling
lasers
skin boosters
PRP
Recommended Treatment Protocol
Rejuran works gradually and usually requires a series of treatments.
Typical protocol:
Initial course
3 to 4 treatments
spaced 3–4 weeks apart
Maintenance
every 6–12 months
Results generally begin to appear 2–4 weeks after treatment and improve progressively as collagen production increases.
What the Treatment Is Like
The procedure typically involves micro-injections into the dermis using a very fine needle.
Treatment time:
30–45 minutes.
Common immediate effects include:
small bumps at injection sites
redness
mild swelling
These typically resolve within 24–48 hours.
Why Salmon DNA Is Used
Salmon DNA is used because it has high structural similarity to human DNA, allowing the body to easily accept and utilize the molecules.
Because of this compatibility, salmon-derived polynucleotides are widely used in regenerative medicine to support tissue repair and healing.